App Information

  • Developer : EONE-DIAGNOMICS Genome Center
  • Report Updated :
  • App Version : 1.0
  • Required File Format : VCF
  • Report Language : English
  • Category : Health


EONE-DIAGNOMICS Genome Center Health
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Inherited mutations in the BRCA1 and BRCA2 genes lead to hereditary breast and ovarian cancer (HBOC) syndrome, an autosomal dominant disorder associated primarily with increased risk of early-onset, breast (in both female and male) and ovarian cancer.HBOC syndrome accounts for about 5-10% of all female breast cancers, an estimated 5-20% of male breast cancers, and 15-20% of familial breast cancers.Less common mutations in other tum or suppressor genes have also been associated with an increased risk of breast cancer.BRCARE Plus test is designed to detect mutations in TP53, PTEN, CDH1, PALB2 as well as BRCA1 and BRCA2. The average cumulative risks in carriers of germline mutations in these genes by age 70 are as follows.

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